LIN28B Antikörper (AA 166-250)

Produktnummer ABIN7165750

Produktdetails anti-LIN28B Antikörper

Target: LIN28B (Lin-28 Homolog B (LIN28B))

Bindungsspezifität: AA 166-250

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIN28B Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Protein lin-28 homolog B protein (166-250AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LIN28B

Target: LIN28B (Lin-28 Homolog B (LIN28B))

Andere Bezeichnung: LIN28B (LIN28B Produkte)

Synonyme: csdd2 antikoerper, LIN-28 antikoerper, CSDD2 antikoerper, 2810403D23Rik antikoerper, D030047M17Rik antikoerper, Lin-28.2 antikoerper, lin-28 homolog B antikoerper, lin-28 homolog B S homeolog antikoerper, lin-28 homolog B (C. elegans) antikoerper, LIN28B antikoerper, lin28b antikoerper, lin28b.S antikoerper, Lin28b antikoerper

Hintergrund:

Background: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5\'-GGAG-3\' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

Aliases: CSDD 2 antibody, CSDD2 antibody, FLJ16517 antibody, Lin 28 homolog B (C. elegans) antibody, Lin 28.2 antibody, Lin-28B antibody, LIN28B antibody, LN28B_HUMAN antibody, Protein lin-28 homolog B antibody

UniProt: Q6ZN17