MAGOH Antikörper (AA 1-146)

Produktnummer ABIN7165791

Produktdetails anti-MAGOH Antikörper

Target: MAGOH (Mago-Nashi Homolog (MAGOH))

Bindungsspezifität: AA 1-146

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAGOH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Protein mago nashi homolog protein (1-146AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAGOH

Target: MAGOH (Mago-Nashi Homolog (MAGOH))

Andere Bezeichnung: MAGOH (MAGOH Produkte)

Synonyme: MAGOH1 antikoerper, MAGOHA antikoerper, Mago-m antikoerper, Mos2 antikoerper, MAGOH antikoerper, zgc:112220 antikoerper, mago antikoerper, xl-mago antikoerper, CG9401 antikoerper, Dm MGN antikoerper, DmMago antikoerper, Dmel\CG9401 antikoerper, MGN antikoerper, Mago antikoerper, Magoh antikoerper, l(2)57Ca antikoerper, mgn antikoerper, magoh antikoerper, mago homolog, exon junction complex core component antikoerper, protein mago nashi homolog antikoerper, mago homolog, exon junction complex core component L homeolog antikoerper, mago nashi antikoerper, MAGOH antikoerper, Magoh antikoerper, LOC736868 antikoerper, magoh antikoerper, magoh.L antikoerper, mago antikoerper, LOC106584057 antikoerper

Hintergrund:

Background: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.

Aliases: Mago nashi homolog proliferation associated (Drosophila) antibody, Mago nashi protein homolog antibody, magoh antibody, MAGOHA antibody, MGN_HUMAN antibody, Protein mago nashi homolog antibody

UniProt: P61326