MEFV Antikörper (AA 268-374)

Produktnummer ABIN7166884

Produktdetails anti-MEFV Antikörper

Target: MEFV (Mediterranean Fever (MEFV))

Bindungsspezifität: AA 268-374

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEFV Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Pyrin protein (268-374AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MEFV

Target: MEFV (Mediterranean Fever (MEFV))

Andere Bezeichnung: MEFV (MEFV Produkte)

Synonyme: pyrin antikoerper, MEFV antikoerper, FMF antikoerper, MEF antikoerper, TRIM20 antikoerper, rfp domain antikoerper, MEFV, pyrin innate immunity regulator antikoerper, Mediterranean fever antikoerper, MEFV antikoerper, Mefv antikoerper

Hintergrund:

Background: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).

Aliases: FMF antibody, Marenostrin antibody, Mediterranean fever antibody, Mediterranean fever protein antibody, MEF antibody, Mefv antibody, MEFV_HUMAN antibody, Pyrin antibody, TRIM20 antibody

UniProt: O15553

Pathways: Positive Regulation of Endopeptidase Activity