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MEFV Antikörper (AA 268-374) (Biotin)

MEFV Reaktivität: Human ELISA Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN7166885
  • Target Alle MEFV Antikörper anzeigen
    MEFV (Mediterranean Fever (MEFV))
    Bindungsspezifität
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 268-374
    Reaktivität
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 19
    • 2
    • 1
    Kaninchen
    Klonalität
    • 21
    • 1
    Polyklonal
    Konjugat
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser MEFV Antikörper ist konjugiert mit Biotin
    Applikation
    • 18
    • 14
    • 2
    • 1
    • 1
    • 1
    ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Pyrin protein (268-374AA)
    Isotyp
    IgG
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    MEFV (Mediterranean Fever (MEFV))
    Andere Bezeichnung
    MEFV (MEFV Produkte)
    Synonyme
    pyrin antikoerper, MEFV antikoerper, FMF antikoerper, MEF antikoerper, TRIM20 antikoerper, rfp domain antikoerper, MEFV, pyrin innate immunity regulator antikoerper, Mediterranean fever antikoerper, MEFV antikoerper, Mefv antikoerper
    Hintergrund

    Background: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).

    Aliases: FMF antibody, Marenostrin antibody, Mediterranean fever antibody, Mediterranean fever protein antibody, MEF antibody, Mefv antibody, MEFV_HUMAN antibody, Pyrin antibody, TRIM20 antibody

    UniProt
    O15553
    Pathways
    Positive Regulation of Endopeptidase Activity
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