HBXIP Antikörper (AA 1-91)

Produktnummer ABIN7167073

Produktdetails anti-HBXIP Antikörper

Target: HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))

Bindungsspezifität: AA 1-91

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HBXIP Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ragulator complex protein LAMTOR5 protein (1-91AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu HBXIP

Target: HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))

Andere Bezeichnung: LAMTOR5 (HBXIP Produkte)

Synonyme: HBXIP antikoerper, xip antikoerper, XIP antikoerper, 1110003H18Rik antikoerper, Hbxip antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 antikoerper, Hepatitis B virus X-interacting protein antikoerper, LAMTOR5 antikoerper, xip antikoerper, Lamtor5 antikoerper

Substanzklasse: Viral Protein

Hintergrund:

Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Aliases: HBV X interacting protein antibody, HBV X-interacting protein antibody, HBX interacting protein antibody, HBX-interacting protein antibody, hbxip antibody, HBXIP_HUMAN antibody, Hepatitis B virus X interacting protein antibody, Hepatitis B virus X-interacting protein antibody, LAMTOR5 antibody, Late endosomal/lysosomal adaptor MAPK and MTOR activator 5 antibody, MGC71071 antibody, Ragulator complex protein LAMTOR5 antibody, XIP antibody

UniProt: O43504

Pathways: PI3K-Akt Signalweg, Regulation of Cell Size