RICTOR Antikörper (AA 1-245)

Produktnummer ABIN7167113

Produktdetails anti-RICTOR Antikörper

Target: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Bindungsspezifität: AA 1-245

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RICTOR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Rapamycin-insensitive companion of mTOR protein (1-245AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RICTOR

Target: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Andere Bezeichnung: RICTOR (RICTOR Produkte)

Synonyme: PIA antikoerper, mAVO3 antikoerper, 4921505C17Rik antikoerper, 6030405M08Rik antikoerper, AVO3 antikoerper, AW492497 antikoerper, D530039E11Rik antikoerper, Fyb antikoerper, RPTOR independent companion of MTOR complex 2 antikoerper, RPTOR independent companion of MTOR, complex 2 antikoerper, RICTOR antikoerper, Rictor antikoerper

Hintergrund:

Background: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \\\'Ser-473\\\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \\\'Thr-308\\\' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at \\\'Ser-422\\\'. mTORC2 also modulates the phosphorylation of PRKCA on \\\'Ser-657\\\'. Plays an essential role in embryonic growth and development.

Aliases: AVO3 antibody, AVO3 homolog antibody, DKFZp686B11164 antibody, hAVO3 antibody, KIAA1999 antibody, Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody, mAVO3 antibody, MGC39830 antibody, PIA antibody, Pianissimo antibody, Rapamycin insensitive companion of mTOR antibody, Rapamycin-insensitive companion of mTOR antibody, Rictor antibody, RICTR antibody, RICTR_HUMAN antibody, RPTOR independent companion of MTOR complex 2 antibody, TORC2 specific protein AVO3 antibody

UniProt: Q6R327

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events