FIP200 Antikörper (AA 1544-1594) (Biotin)

Produktnummer ABIN7167418

Dieses Anti-FIP200-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FIP200 in ELISA. Geeignet für Human.

Kurzübersicht für FIP200 Antikörper (AA 1544-1594) (Biotin) (ABIN7167418)

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FIP200 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-FIP200 Antikörper (Biotin)

Bindungsspezifität: AA 1544-1594

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human RB1-inducible coiled-coil protein 1 protein (1544-1594AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FIP200

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Andere Bezeichnung: RB1CC1

Hintergrund:

Background: Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.

Aliases: FAK family kinase-interacting protein of 200 kDa antibody, FIP200 antibody, RB1-inducible coiled-coil protein 1 antibody, RB1CC1 antibody, RBCC1_HUMAN antibody

UniProt: Q8TDY2

Pathways: Regulation of Cell Size, Autophagie