p130 Antikörper (AA 417-616)

Produktnummer ABIN7167791

Produktdetails anti-p130 Antikörper

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Bindungsspezifität: AA 417-616

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p130 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Retinoblastoma-like protein 2 protein (417-616AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu p130

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Andere Bezeichnung: RBL2 (RBL2 Produkte)

Synonyme: RBL2 antikoerper, RBR2 antikoerper, RRB2a antikoerper, PRB2 antikoerper, RBR-2 antikoerper, Rb2 antikoerper, p130 antikoerper, P130 antikoerper, retinoblastoma-like 2 (p130) antikoerper, RB transcriptional corepressor like 2 antikoerper, related to retinoblastoma 2 antikoerper, RBL2 antikoerper, LOC541652 antikoerper, Rbl2 antikoerper

Hintergrund:

Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Aliases: 130 kDa retinoblastoma associated protein antibody, 130 kDa retinoblastoma-associated protein antibody, IB4 antibody, p130 antibody, PPAR-alpha-interacting complex protein 128 antibody, PRB2 antibody, Rb2 antibody, Rbl2 antibody, RBL2_HUMAN antibody, RBR 2 antibody, RBR-2 antibody, RBR2 antibody, Retinoblastoma like 2 antibody, Retinoblastoma-like protein 2 antibody, Retinoblastoma-related protein 2 antibody, RIC128 antibody

UniProt: Q08999

Pathways: Zellzyklus, Mitotic G1-G1/S Phases