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p130 Antikörper (AA 417-616)

RBL2 Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7167791
  • Target Alle p130 (RBL2) Antikörper anzeigen
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 417-616
    Reaktivität
    • 70
    • 29
    • 27
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 63
    • 8
    Kaninchen
    Klonalität
    • 64
    • 7
    Polyklonal
    Konjugat
    • 30
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser p130 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 27
    • 14
    • 13
    • 13
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Retinoblastoma-like protein 2 protein (417-616AA)
    Isotyp
    IgG
    Top Product
    Discover our top product RBL2 Primärantikörper
  • Applikationshinweise
    Recommended dilution: IHC:1:200-1:500,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    Andere Bezeichnung
    RBL2 (RBL2 Produkte)
    Synonyme
    RBL2 antikoerper, RBR2 antikoerper, RRB2a antikoerper, PRB2 antikoerper, RBR-2 antikoerper, Rb2 antikoerper, p130 antikoerper, P130 antikoerper, retinoblastoma-like 2 (p130) antikoerper, RB transcriptional corepressor like 2 antikoerper, related to retinoblastoma 2 antikoerper, RBL2 antikoerper, LOC541652 antikoerper, Rbl2 antikoerper
    Hintergrund

    Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

    Aliases: 130 kDa retinoblastoma associated protein antibody, 130 kDa retinoblastoma-associated protein antibody, IB4 antibody, p130 antibody, PPAR-alpha-interacting complex protein 128 antibody, PRB2 antibody, Rb2 antibody, Rbl2 antibody, RBL2_HUMAN antibody, RBR 2 antibody, RBR-2 antibody, RBR2 antibody, Retinoblastoma like 2 antibody, Retinoblastoma-like protein 2 antibody, Retinoblastoma-related protein 2 antibody, RIC128 antibody

    UniProt
    Q08999
    Pathways
    Zellzyklus, Mitotic G1-G1/S Phases
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