RRM2B Antikörper (AA 1-351)

Produktnummer ABIN7168147

Produktdetails anti-RRM2B Antikörper

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Bindungsspezifität: AA 1-351

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRM2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 B protein (1-351AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RRM2B

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Andere Bezeichnung: RRM2B (RRM2B Produkte)

Synonyme: p53r2 antikoerper, RRM2B antikoerper, MTDPS8A antikoerper, MTDPS8B antikoerper, P53R2 antikoerper, p53R2 antikoerper, ribonucleotide reductase M2 B (TP53 inducible) S homeolog antikoerper, ribonucleotide reductase regulatory TP53 inducible subunit M2B antikoerper, ribonucleotide reductase M2 B (TP53 inducible) antikoerper, rrm2b.S antikoerper, RRM2B antikoerper, rrm2b antikoerper, Rrm2b antikoerper

Hintergrund:

Background: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

Aliases: DKFZp686M05248 antibody, MGC102856 antibody, MGC42116 antibody, MTDPS8A antibody, MTDPS8B antibody, p53 inducible ribonucleotide reductase small subunit 2 homolog antibody, p53 inducible ribonucleotide reductase small subunit 2 like protein antibody, P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody, p53 R2 antibody, p53-inducible ribonucleotide reductase small subunit 2-like protein antibody, p53R2 antibody, Ribonucleoside diphosphate reductase M2 subunit B antibody, Ribonucleoside-diphosphate reductase subunit M2 B antibody, Ribonucleotide reductase M2 B (TP53 inducible) antibody, Ribonucleotide reductase M2 B antibody, Ribonucleotide reductase small subunit like 2 p53 inducible antibody, RIR2B_HUMAN antibody, RRM 2B antibody, RRM2B antibody, TP53 inducible ribonucleotide reductase M2 B antibody, TP53-inducible ribonucleotide reductase M2 B antibody

UniProt: Q7LG56

Pathways: p53 Signalweg, Negative Regulation of intrinsic apoptotic Signaling