RBM4 Antikörper (AA 121-205) (FITC)

Produktnummer ABIN7168347

Produktdetails anti-RBM4 Antikörper (FITC)

Target: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Bindungsspezifität: AA 121-205

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBM4 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human RNA-binding protein 4 protein (121-205AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RBM4

Target: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Andere Bezeichnung: RBM4 (RBM4 Produkte)

Hintergrund:

Background: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5\\\'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3\\\'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3\\\'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5\\\'-CGCGCG[GCA]-3\\\' motif in vitro.

Aliases: dkfzp547k0918 antibody, hLark antibody, lark antibody, Lark homolog antibody, lark homologue antibody, mgc75138 antibody, RBM4 antibody, rbm4 lark antibody, RBM4_HUMAN antibody, RNA binding motif 4 antibody, RNA binding motif 4a antibody, RNA-binding motif protein 4 antibody, RNA-binding motif protein 4a antibody, RNA-binding protein 4 antibody

UniProt: Q9BWF3

Pathways: Regulation of Muscle Cell Differentiation, Photoperiodism