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RC3H2 Antikörper (AA 251-506) (FITC)

RC3H2 Reaktivität: Human Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN7168434
  • Target Alle RC3H2 Produkte
    RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))
    Bindungsspezifität
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 251-506
    Reaktivität
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 9
    • 1
    Kaninchen
    Klonalität
    • 10
    Polyklonal
    Konjugat
    • 7
    • 1
    • 1
    • 1
    Dieser RC3H2 Antikörper ist konjugiert mit FITC
    Applikation
    Bitte anfragen
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Roquin-2 protein (251-506AA)
    Isotyp
    IgG
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))
    Andere Bezeichnung
    RC3H2 (RC3H2 Produkte)
    Synonyme
    Mnab antikoerper, MNAB antikoerper, RNF164 antikoerper, 2900024N03Rik antikoerper, 9430019J22Rik antikoerper, D930043C02Rik antikoerper, Rnf164 antikoerper, ring finger and CCCH-type domains 2 antikoerper, ring finger and CCCH-type zinc finger domains 2 antikoerper, Rc3h2 antikoerper, RC3H2 antikoerper
    Hintergrund

    Background: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3\'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).

    Aliases: 2900024N03Rik antibody, 9430019J22Rik antibody, D930043C02Rik antibody, FLJ20301 antibody, FLJ20713 antibody, Membrane associated DNA binding protein antibody, Membrane associated nucleic acid binding protein antibody, Membrane-associated nucleic acid-binding protein antibody, MGC52176 antibody, MNAB antibody, OTTHUMP00000022076 antibody, OTTHUMP00000022077 antibody, OTTMUSP00000013545 antibody, OTTMUSP00000013546 antibody, Rc3h2 antibody, RC3H2_HUMAN antibody, Ring finger and CCCH type domains 2 antibody, RING finger and CCCH type zinc finger domain containing protein 2 antibody, Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody, ring finger and CCCH-type zinc finger domains 2 antibody, RING finger protein 164 antibody, RNF164 antibody, roquin-2 antibody, RP23-321B3.1 antibody

    UniProt
    Q9HBD1
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