HTRA1 Antikörper (AA 23-248)

Produktnummer ABIN7168916

Produktdetails anti-HTRA1 Antikörper

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Bindungsspezifität: AA 23-248

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HTRA1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine protease HTRA1 protein (23-248AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu HTRA1

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Andere Bezeichnung: HTRA1 (HTRA1 Produkte)

Synonyme: htra1 antikoerper, zgc:92029 antikoerper, zgc:172061 antikoerper, l56 antikoerper, htra antikoerper, Xhtra1 antikoerper, prss11 antikoerper, MGC145723 antikoerper, ARMD7 antikoerper, CARASIL antikoerper, HtrA antikoerper, L56 antikoerper, ORF480 antikoerper, PRSS11 antikoerper, AI429470 antikoerper, HTRA antikoerper, Prss11 antikoerper, RSPP11 antikoerper, HTRA1 antikoerper, HtrA serine peptidase 1a antikoerper, HtrA serine peptidase 1 antikoerper, HtrA serine peptidase 1b antikoerper, Serine protease HTRA1 antikoerper, HtrA serine peptidase 1 S homeolog antikoerper, htra1a antikoerper, HTRA1 antikoerper, htra1b antikoerper, htra1 antikoerper, Htra1 antikoerper, htra1.S antikoerper

Hintergrund:

Background: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Aliases: ARMD7 antibody, CARASIL antibody, High-temperature requirement A serine peptidase 1 antibody, HtrA antibody, HtrA serine peptidase 1 antibody, HTRA1 antibody, HTRA1_HUMAN antibody, IGFBP5 protease antibody, L56 antibody, ORF480 antibody, Protease serine 11 (IGF binding) antibody, protease serine 11 antibody, PRSS11 antibody, Serine protease 11 antibody, Serine protease HTRA1 antibody, Serine protease HTRA1 precursor antibody

UniProt: Q92743

Pathways: Growth Factor Binding