SRSF1 Antikörper (AA 1-248)

Produktnummer ABIN7168966

Produktdetails anti-SRSF1 Antikörper

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Bindungsspezifität: AA 1-248

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRSF1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/arginine-rich splicing factor 1 protein (1-248AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SRSF1

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Andere Bezeichnung: SRSF1 (SRSF1 Produkte)

Hintergrund:

Background: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5\\\'- and 3\\\'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5\\\'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5\\\'-RGAAGAAC-3\\\' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5\\\'-CGAGGCG-3\\\' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

Aliases: Alternative splicing factor 1 antibody, Alternative-splicing factor 1 antibody, arginine/serine-rich 1 antibody, ASF 1 antibody, ASF antibody, ASF-1 antibody, ASF1 antibody, FLJ53078 antibody, MGC5228 antibody, P33 subunit antibody, Pre mRNA splicing factor SF2 P33 subunit antibody, pre-mRNA-splicing factor SF2 antibody, Serine/arginine-rich splicing factor 1 antibody, SF2 antibody, SF2P33 antibody, SFRS1 antibody, Splicing factor 2 alternate splicing factor antibody, Splicing factor 2 antibody, Splicing factor antibody, Splicing factor arginine/serine rich 1 antibody, SR Splicing factor 1 antibody, SRp30a antibody, srsf1 antibody, SRSF1_HUMAN antibody

UniProt: Q07955

Pathways: Ribonucleoprotein Complex Subunit Organization