PKN2 Antikörper (AA 925-969)

Produktnummer ABIN7169080

Produktdetails anti-PKN2 Antikörper

Target: PKN2 (Protein Kinase N2 (PKN2))

Bindungsspezifität: AA 925-969

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKN2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase N2 protein (925-969AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PKN2

Target: PKN2 (Protein Kinase N2 (PKN2))

Andere Bezeichnung: PKN2 (PKN2 Produkte)

Synonyme: PAK2 antikoerper, PRK2 antikoerper, PRKCL2 antikoerper, PRO2042 antikoerper, Pak-2 antikoerper, 6030436C20Rik antikoerper, AI507382 antikoerper, Prkcl2 antikoerper, Stk7 antikoerper, pak2 antikoerper, prk2 antikoerper, pak-2 antikoerper, pro2042 antikoerper, PKN2 antikoerper, si:ch211-83f14.1 antikoerper, wu:fa97c07 antikoerper, protein kinase N2 antikoerper, protein kinase N2 L homeolog antikoerper, PKN2 antikoerper, Pkn2 antikoerper, pkn2.L antikoerper, pkn2 antikoerper

Hintergrund:

Background: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.

Aliases: Cardiolipin activated protein kinase Pak2 antibody, MGC150606 antibody, MGC71074 antibody, PAK 2 antibody, PAK2 antibody, PKN gamma antibody, PKN2 antibody, PKN2_HUMAN antibody, PRK2 antibody, PRKCL2 antibody, PRO2042 antibody, Protein kinase C like 2 antibody, Protein kinase C related kinase 2 antibody, Protein kinase C-like 2 antibody, Protein kinase N2 antibody, Protein-kinase C-related kinase 2 antibody, Serine/threonine-protein kinase N2 antibody

UniProt: Q16513

Pathways: Cell-Cell Junction Organization