PAK4 Antikörper (AA 1-426)

Produktnummer ABIN7169132

Produktdetails anti-PAK4 Antikörper

Target: PAK4 (P21-Activated Kinase 4 (PAK4))

Bindungsspezifität: AA 1-426

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase PAK 4 protein (1-426AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PAK4

Target: PAK4 (P21-Activated Kinase 4 (PAK4))

Andere Bezeichnung: PAK4 (PAK4 Produkte)

Synonyme: 5730488L07Rik antikoerper, AW555722 antikoerper, mKIAA1142 antikoerper, im:5916170 antikoerper, wu:fd12b01 antikoerper, zgc:92014 antikoerper, p21 (RAC1) activated kinase 4 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 4 antikoerper, PAK4 antikoerper, Pak4 antikoerper, pak4 antikoerper

Hintergrund:

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

Aliases: KIAA1142 antibody, p21 activated kinase 4 antibody, p21 Cdc42/Rac1-actiated kinase 4 antibody, P21 protein (Cdc42/Rac) activated kinase 4 antibody, p21(CDKN1A) activated kinase 4 antibody, p21-activated kinase 4 antibody, PAK 4 antibody, PAK-4 antibody, Pak4 antibody, PAK4_HUMAN antibody, Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibody, Serine threonine kinase PAK 4 antibody, Serine/threonine protein kinase PAK 4 antibody, Serine/threonine protein kinase PAK4 antibody, Serine/threonine-protein kinase PAK 4 antibody

UniProt: O96013

Pathways: RTK Signalweg