PIM3 Antikörper (AA 278-326)

Produktnummer ABIN7169149

Produktdetails anti-PIM3 Antikörper

Target: PIM3 (Pim-3 Oncogene (PIM3))

Bindungsspezifität: AA 278-326

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIM3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase pim-3 protein (278-326AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIM3

Target: PIM3 (Pim-3 Oncogene (PIM3))

Andere Bezeichnung: PIM3 (PIM3 Produkte)

Synonyme: pim1-a antikoerper, pim-3 antikoerper, BC026639 antikoerper, Kid1 antikoerper, Serine/threonine-protein kinase Pim-3 antikoerper, Pim-3 proto-oncogene, serine/threonine kinase S homeolog antikoerper, Pim-3 proto-oncogene, serine/threonine kinase antikoerper, pim-3 oncogene antikoerper, proviral integration site 3 antikoerper, pim3 antikoerper, pim3.S antikoerper, PIM3 antikoerper, Pim3 antikoerper

Hintergrund:

Background: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Aliases: Kid 1 antibody, Kid1 antibody, Kinase induced by depolarization antibody, ONCOGENE PIM3 antibody, PIM 3 antibody, Pim 3 oncogene antibody, Pim-3 proto-oncogene, serine/threonine kinase antibody, PIM3 antibody, Pim3 oncogene antibody, PIM3_HUMAN antibody, Protein kinase Kid 1 antibody, Protein kinase Kid1 antibody, Serine/threonine kinase Pim 3 antibody, Serine/threonine kinase Pim3 antibody, Serine/threonine protein kinase Pim 3 antibody, Serine/threonine protein kinase Pim3 antibody, Serine/threonine-protein kinase Pim-3 antibody

UniProt: Q86V86

Pathways: Negative Regulation of Hormone Secretion