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TBK1 Antikörper (AA 364-585)

TBK1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7169195
  • Target Alle TBK1 Antikörper anzeigen
    TBK1 (TANK-Binding Kinase 1 (TBK1))
    Bindungsspezifität
    • 10
    • 10
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 364-585
    Reaktivität
    • 77
    • 55
    • 29
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 73
    • 18
    • 1
    Kaninchen
    Klonalität
    • 72
    • 20
    Polyklonal
    Konjugat
    • 46
    • 8
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Dieser TBK1 Antikörper ist unkonjugiert
    Applikation
    • 58
    • 42
    • 25
    • 10
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Serine/threonine-protein kinase TBK1 protein (364-585AA)
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:500, IF:1:50-1:500,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    TBK1 (TANK-Binding Kinase 1 (TBK1))
    Andere Bezeichnung
    TBK1 (TBK1 Produkte)
    Synonyme
    nak antikoerper, t2k antikoerper, TBK1 antikoerper, wu:fk70c05 antikoerper, zgc:136548 antikoerper, NAK antikoerper, T2K antikoerper, 1200008B05Rik antikoerper, AI462036 antikoerper, AW048562 antikoerper, TANK binding kinase 1 L homeolog antikoerper, TANK binding kinase 1 antikoerper, TANK-binding kinase 1 antikoerper, tbk1.L antikoerper, TBK1 antikoerper, tbk1 antikoerper, Tbk1 antikoerper
    Hintergrund

    Background: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on \'Ser-177\', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

    Aliases: EC 2.7.11.1 antibody, FLJ11330 antibody, FTDALS4 antibody, NAK antibody, NF kappa B activating kinase antibody, NF kB activating kinase antibody, NF-kappa-B-activating kinase antibody, Serine/threonine protein kinase TBK 1 antibody, Serine/threonine protein kinase TBK1 antibody, Serine/threonine-protein kinase TBK1 antibody, T2K antibody, TANK binding kinase 1 antibody, TANK-binding kinase 1 antibody, TBK 1 antibody, Tbk1 antibody, TBK1_HUMAN antibody

    UniProt
    Q9UHD2
    Pathways
    TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom
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