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ULK2 Antikörper (AA 211-276)

ULK2 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7169209
  • Target Alle ULK2 Antikörper anzeigen
    ULK2 (Unc-51 Like Kinase 2 (ULK2))
    Bindungsspezifität
    • 12
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 211-276
    Reaktivität
    • 64
    • 17
    • 8
    Human
    Wirt
    • 55
    • 9
    Kaninchen
    Klonalität
    • 56
    • 8
    Polyklonal
    Konjugat
    • 33
    • 7
    • 6
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Dieser ULK2 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 44
    • 14
    • 11
    • 10
    • 7
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Serine/threonine-protein kinase ULK2 protein (211-276AA)
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ULK2 (Unc-51 Like Kinase 2 (ULK2))
    Andere Bezeichnung
    ULK2 (ULK2 Produkte)
    Synonyme
    ULK2 antikoerper, ATG1B antikoerper, Unc51.2 antikoerper, A830085I22Rik antikoerper, AU015340 antikoerper, mKIAA0623 antikoerper, unc-51 like autophagy activating kinase 2 antikoerper, unc-51 like kinase 2 antikoerper, ULK2 antikoerper, Ulk2 antikoerper, ulk2 antikoerper
    Hintergrund

    Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR, however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

    Aliases: ATG1B antibody, KIAA0623 antibody, Serine/threonine protein kinase ULK2 antibody, Serine/threonine-protein kinase ULK2 antibody, ULK2 antibody, ULK2_HUMAN antibody, Unc 51 (C. elegans) like kinase 2 antibody, Unc 51 like autophagy activating kinase 2 antibody, Unc 51 like kinase 2 antibody, Unc-51-like kinase 2 antibody, Unc51.2 antibody

    UniProt
    Q8IYT8
    Pathways
    Regulation of Cell Size, Autophagie
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