ULK3 Antikörper (AA 44-240)
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- Target Alle ULK3 Antikörper anzeigen
- ULK3 (Unc-51-Like Kinase 3 (ULK3))
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Bindungsspezifität
- AA 44-240
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ULK3 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC)
- Kreuzreaktivität
- Human
- Aufreinigung
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Serine/threonine-protein kinase ULK3 protein (44-240AA)
- Isotyp
- IgG
- Top Product
- Discover our top product ULK3 Primärantikörper
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- Applikationshinweise
- Recommended dilution: IHC:1:20-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- ULK3 (Unc-51-Like Kinase 3 (ULK3))
- Andere Bezeichnung
- ULK3 (ULK3 Produkte)
- Synonyme
- zgc:162196 antikoerper, 1200015E14Rik antikoerper, unc-51 like kinase 3 antikoerper, unc-51 like kinase 3 L homeolog antikoerper, unc-51-like kinase 3 antikoerper, ULK3 antikoerper, ulk3 antikoerper, Ulk3 antikoerper, ulk3.L antikoerper
- Hintergrund
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Background: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Aliases: DKFZP434C131 antibody, FLJ90566 antibody, Serine/threonine-protein kinase ULK3 antibody, Ulk3 antibody, ULK3_HUMAN antibody, unc 51 like kinase 3 (C. elegans) antibody, Unc-51-like kinase 3 antibody
- UniProt
- Q6PHR2
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