WNK1 Antikörper (AA 1-207)

Produktnummer ABIN7169222

Produktdetails anti-WNK1 Antikörper

Target: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Bindungsspezifität: AA 1-207

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WNK1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase WNK1 protein (1-207AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu WNK1

Target: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Andere Bezeichnung: WNK1 (WNK1 Produkte)

Synonyme: HSAN2 antikoerper, HSN2 antikoerper, KDP antikoerper, PRKWNK1 antikoerper, PSK antikoerper, p65 antikoerper, WNK1 antikoerper, kdp antikoerper, psk antikoerper, hsn2 antikoerper, hsan2 antikoerper, pha2c antikoerper, prkwnk1 antikoerper, 6430573H23Rik antikoerper, EG406236 antikoerper, Hsn2 antikoerper, Prkwnk1 antikoerper, mKIAA0344 antikoerper, ATWNK1 antikoerper, T9J14.14 antikoerper, T9J14_14 antikoerper, ZIK4 antikoerper, with no lysine (K) kinase 1 antikoerper, WNK lysine deficient protein kinase 1 antikoerper, WNK lysine deficient protein kinase 1 L homeolog antikoerper, serine/threonine-protein kinase WNK1 antikoerper, with no lysine (K) kinase 1 antikoerper, WNK1 antikoerper, wnk1.L antikoerper, wnk1 antikoerper, LOC100056745 antikoerper, Wnk1 antikoerper

Hintergrund:

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

Aliases: Erythrocyte 65 kDa protein antibody, HSAN2 antibody, HSN2 antibody, hWNK1 antibody, KDP antibody, KIAA0344 antibody, Kinase deficient protein antibody, MGC163339 antibody, MGC163341 antibody, p65 antibody, PPP1R167 antibody, PRKWNK1 antibody, Prostate derived sterile 20 like kinase antibody, Protein kinase lysine deficient 1 antibody, Protein kinase lysine-deficient 1 antibody, Protein kinase with no lysine 1 antibody, Protein phosphatase 1, regulatory subunit 167 antibody, PSK antibody, Serine/threonine protein kinase WNK1 1 antibody, Serine/threonine protein kinase WNK1 2 antibody, Serine/threonine protein kinase WNK1 antibody, Serine/threonine-protein kinase WNK1 antibody, With no K antibody, WNK lysine deficient protein kinase 1 antibody, WNK lysine deficient protein kinase 1 isoform antibody, WNK1 antibody, WNK1_HUMAN antibody

UniProt: Q9H4A3