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SH2D1B Antikörper (AA 1-77)

SH2D1B Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7169453
  • Target Alle SH2D1B Antikörper anzeigen
    SH2D1B (SH2 Domain Containing 1B (SH2D1B))
    Bindungsspezifität
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-77
    Reaktivität
    • 24
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 17
    • 5
    • 2
    Kaninchen
    Klonalität
    • 21
    • 3
    Polyklonal
    Konjugat
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SH2D1B Antikörper ist unkonjugiert
    Applikation
    • 11
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human SH2 domain-containing protein 1B protein (1-77AA)
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SH2D1B (SH2 Domain Containing 1B (SH2D1B))
    Andere Bezeichnung
    SH2D1B (SH2D1B Produkte)
    Synonyme
    EAT2 antikoerper, Sh2d1b1 antikoerper, RGD1563935 antikoerper, SH2 domain containing 1B antikoerper, SH2D1B antikoerper, Sh2d1b antikoerper
    Hintergrund

    Background: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation, downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).

    Aliases: SH2D1B antibody, EAT2 antibody, SH2 domain-containing protein 1B antibody, EWS/FLI1-activated transcript 2 antibody, EAT-2 antibody

    UniProt
    O14796
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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