Shugoshin Antikörper (AA 260-439) (Biotin)

Produktnummer ABIN7169546

Produktdetails anti-Shugoshin Antikörper (Biotin)

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Bindungsspezifität: AA 260-439

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Shugoshin Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Shugoshin 1 protein (260-439AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Shugoshin

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Andere Bezeichnung: SGO1 (SGOL1 Produkte)

Synonyme: sgo1 antikoerper, NY-BR-85 antikoerper, SGO antikoerper, Sgo1 antikoerper, 3300001M08Rik antikoerper, C81037 antikoerper, shugoshin 1 antikoerper, shugoshin centromeric cohesion 1 antikoerper, shugoshin 1 L homeolog antikoerper, Sgo1 antikoerper, sgo1 antikoerper, sgo1.L antikoerper, SGO1 antikoerper

Hintergrund:

Background: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.

Aliases: hSgo 1 antibody, hSgo1 antibody, NY BR 85 antibody, Serologically defined breast cancer antigen NY BR 85 antibody, Serologically defined breast cancer antigen NY-BR-85 antibody, SGO 1 antibody, SGO antibody, SGO L1 antibody, SGO1 antibody, SGOL 1 antibody, SGOL1 antibody, SGOL1_HUMAN antibody, Shugoshin 1AB protein antibody, Shugoshin 1CD protein antibody, Shugoshin 1EFprotein antibody, Shugoshin 1GH protein antibody, Shugoshin 1KL protein antibody, Shugoshin like 1 (S. pombe) antibody, Shugoshin like 1 antibody, Shugoshin-like 1 antibody

UniProt: Q5FBB7

Pathways: Maintenance of Protein Location