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SNX6 Antikörper (AA 1-290)

SNX6 Reaktivität: Human ELISA, WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7170402
  • Target Alle SNX6 Antikörper anzeigen
    SNX6 (Sorting Nexin 6 (SNX6))
    Bindungsspezifität
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-290
    Reaktivität
    • 34
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 26
    • 9
    Kaninchen
    Klonalität
    • 26
    • 9
    Polyklonal
    Konjugat
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SNX6 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Sorting nexin-6 protein (1-290AA)
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SNX6 (Sorting Nexin 6 (SNX6))
    Andere Bezeichnung
    SNX6 (SNX6 Produkte)
    Synonyme
    MGC75952 antikoerper, MGC80251 antikoerper, im:7146294 antikoerper, wu:fa55b10 antikoerper, zgc:110798 antikoerper, MSTP010 antikoerper, TFAF2 antikoerper, 2010006G21Rik antikoerper, 2610032J07Rik antikoerper, 2810425K19Rik antikoerper, AU018928 antikoerper, C85963 antikoerper, sorting nexin 6 antikoerper, sorting nexin 6 L homeolog antikoerper, snx6 antikoerper, snx6.L antikoerper, SNX6 antikoerper, Snx6 antikoerper
    Hintergrund

    Background: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

    Aliases: SNX6 antibody, Sorting nexin-6 antibody, TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6 antibody, N-terminally processed] antibody

    UniProt
    Q9UNH7
    Pathways
    EGFR Signaling Pathway
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