Spartan Antikörper (AA 1-239)

Produktnummer ABIN7170650

Produktdetails anti-Spartan Antikörper

Target: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Bindungsspezifität: AA 1-239

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Spartan Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Spartan

Target: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Andere Bezeichnung: SPRTN (C1orf124 Produkte)

Synonyme: Spartan antikoerper, c1orf124 antikoerper, C1orf124 antikoerper, DDDL1880 antikoerper, DVC1 antikoerper, PRO4323 antikoerper, dJ876B10.3 antikoerper, C28H1orf124 antikoerper, SprT-like N-terminal domain antikoerper, sprtn antikoerper, SPRTN antikoerper

Hintergrund:

Background: Regulator of UV-induced DNA damage response: acts as a \'reader\' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

Aliases: SPRTN antibody, C1orf124 antibody, DVC1 antibody, UNQ1880/PRO4323 antibody, SprT-like domain-containing protein Spartan antibody, DNA damage protein targeting VCP antibody, DVC1 antibody, Protein with SprT-like domain at the N terminus antibody, Spartan antibody

UniProt: Q9H040