SMC1A Antikörper (AA 1-130)

Produktnummer ABIN7170857

Produktdetails anti-SMC1A Antikörper

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Bindungsspezifität: AA 1-130

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMC1A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Structural maintenance of chromosomes protein 1A protein (1-130AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMC1A

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Andere Bezeichnung: SMC1A (SMC1A Produkte)

Hintergrund:

Background: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Aliases: Chromosome segregation protein SmcB antibody, DXS423E antibody, KIAA0178 antibody, MGC138332 antibody, Sb1.8 antibody, Segregation of mitotic chromosomes 1 antibody, SMC protein 1A antibody, SMC-1-alpha antibody, SMC-1A antibody, SMC1 (structural maintenance of chromosomes 1 yeast) like 1 antibody, SMC1 antibody, SMC1 structural maintenance of chromosomes 1 like 1 antibody, SMC1A antibody, SMC1A_HUMAN antibody, SMC1alpha antibody, SMC1L1 antibody, SMCB antibody, Structural maintenance of chromosomes 1A antibody, Structural maintenance of chromosomes protein 1A antibody

UniProt: Q14683

Pathways: Stem Cell Maintenance