SMC5 Antikörper (AA 296-403) (Biotin)

Produktnummer ABIN7170871

Produktdetails anti-SMC5 Antikörper (Biotin)

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Bindungsspezifität: AA 296-403

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMC5 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMC5

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Andere Bezeichnung: SMC5 (SMC5 Produkte)

Synonyme: F1N13.60 antikoerper, F1N13_60 antikoerper, structural maintenance of chromosomes 5 antikoerper, SMC-5 antikoerper, SMC5L1 antikoerper, MLZ-453 antikoerper, Smc5l1 antikoerper, mKIAA0594 antikoerper, mSMC5 antikoerper, structural maintenance of chromosomes 5 antikoerper, structural maintenance of chromosomes 5 S homeolog antikoerper, SMC5 antikoerper, smc5 antikoerper, Smc5 antikoerper, smc5.S antikoerper

Hintergrund:

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Aliases: SMC5 antibody, KIAA0594 antibody, SMC5L1 antibody, Structural maintenance of chromosomes protein 5 antibody, SMC protein 5 antibody, SMC-5 antibody, hSMC5 antibody

UniProt: Q8IY18