TNIP1 Antikörper (AA 526-636) (Biotin)

Produktnummer ABIN7172252

Produktdetails anti-TNIP1 Antikörper (Biotin)

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Bindungsspezifität: AA 526-636

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNIP1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human TNFAIP3-interacting protein 1 protein (526-636AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TNIP1

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Andere Bezeichnung: TNIP1 (TNIP1 Produkte)

Synonyme: ABIN-1 antikoerper, NAF1 antikoerper, VAN antikoerper, nip40-1 antikoerper, ABIN antikoerper, ABIN1 antikoerper, AU018810 antikoerper, Naf1 antikoerper, Nef antikoerper, im:7141452 antikoerper, naf1 antikoerper, zgc:158159 antikoerper, tnip1 antikoerper, MGC147597 antikoerper, TNFAIP3 interacting protein 1 antikoerper, TNFAIP3 interacting protein 1 S homeolog antikoerper, TNFAIP3-interacting protein 1 antikoerper, TNIP1 antikoerper, Tnip1 antikoerper, tnip1 antikoerper, tnip1.S antikoerper, LOC100078195 antikoerper

Hintergrund:

Background: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG, proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway, blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity, this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation, this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Aliases: ABIN 1 antibody, HIV-1 Nef-interacting protein antibody, hVAN antibody, KIAA0113 antibody, Naf1 antibody, Nef-associated factor 1 antibody, Nip40-1 antibody, TNFAIP3 interacting protein 1 antibody, TNFAIP3-interacting protein 1 antibody, TNIP-1 antibody, Tnip1 antibody, TNIP1_HUMAN antibody, VAN antibody, Virion-associated nuclear shuttling protein antibody

UniProt: Q15025

Pathways: Activation of Innate immune Response