LRRC32 Antikörper (AA 301-500)

Produktnummer ABIN7172807

Produktdetails anti-LRRC32 Antikörper

Target: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Bindungsspezifität: AA 301-500

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRC32 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Transforming growth factor beta activator LRRC32 protein (301-500AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LRRC32

Target: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Andere Bezeichnung: LRRC32 (LRRC32 Produkte)

Synonyme: D11S833E antikoerper, GARP antikoerper, AI426318 antikoerper, D11S833Eh antikoerper, D7H11S833E antikoerper, EG434215 antikoerper, Garp antikoerper, leucine rich repeat containing 32 antikoerper, LRRC32 antikoerper, Lrrc32 antikoerper

Hintergrund:

Background: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).

Aliases: D11S833E antibody, GARP antibody, Garpin antibody, Glycoprotein A repetitions predominant antibody, Leucine rich repeat containing 32 antibody, Leucine-rich repeat-containing protein 32 antibody, LRC32_HUMAN antibody, LRRC32 antibody

UniProt: Q14392

Pathways: Activated T Cell Proliferation