TMED2 Antikörper (AA 26-111) (Biotin)

Produktnummer ABIN7172976

Produktdetails anti-TMED2 Antikörper (Biotin)

Target: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Bindungsspezifität: AA 26-111

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMED2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Transmembrane emp24 domain-containing protein 2 protein (26-111AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TMED2

Target: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Andere Bezeichnung: TMED2 (TMED2 Produkte)

Synonyme: P24A antikoerper, RNP24 antikoerper, p24 antikoerper, 1110032D12Rik antikoerper, 1810020N21Rik antikoerper, Rnp24 antikoerper, Sid394 antikoerper, p24beta1 antikoerper, Chop24 antikoerper, transmembrane p24 trafficking protein 2 antikoerper, TMED2 antikoerper, Tmed2 antikoerper

Hintergrund:

Background: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

Aliases: coated vesicle membrane protein antibody, Membrane protein p24A antibody, p24 antibody, p24 family protein beta-1 antibody, P24A antibody, p24beta1 antibody, RNP24 antibody, Sid 394 antibody, Sid394 antibody, TMED2 antibody, TMED2_HUMAN antibody, transmembrane emp24 domain trafficking protein 2 antibody, Transmembrane emp24 domain-containing protein 2 antibody

UniProt: Q15363