RAD51 Antikörper (pThr309)

Produktnummer ABIN713111

Produktdetails anti-RAD51 Antikörper

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Bindungsspezifität: pThr309

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD51 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human RAD51 around the phosphorylation site of Thr309 [GE(p-T)RI]

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RAD51

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Andere Bezeichnung: RAD51 (RAD51 Produkte)

Synonyme: BRCC5 antikoerper, HRAD51 antikoerper, HsRad51 antikoerper, HsT16930 antikoerper, MRMV2 antikoerper, RAD51A antikoerper, RECA antikoerper, CRAD51 antikoerper, wu:fb38e12 antikoerper, zgc:77754 antikoerper, RGD1563603 antikoerper, ATRAD51 antikoerper, F22D1.20 antikoerper, F22D1_20 antikoerper, RAS associated with diabetes protein 51 antikoerper, AV304093 antikoerper, Rad51a antikoerper, Reca antikoerper, brcc5 antikoerper, rad51 antikoerper, rad51a antikoerper, reca antikoerper, xrad51 antikoerper, RAD51 recombinase antikoerper, RAS associated with diabetes protein 51 antikoerper, RAD51 recombinase L homeolog antikoerper, RAD51 antikoerper, rad51 antikoerper, Rad51 antikoerper, rad51.L antikoerper

Hintergrund:

Synonyms: RAD51phospho T309, BRCA1/BRCA2 containing complex, subunit 5, BRCC 5, BRCC5, DNA repair protein RAD51 homolog 1, DNA repair protein rhp51, E coli RecA homolog, HGNC:9817, Homolog of E coli RecA, homolog of S cerevisiae RAD51, HRAD51, HsRad51, HsT16930, Rad 51, RAD51 homolog RecA homolog, E. coli S. cerevisiae, RAD51 homolog, RAD51 homolog S. cerevisiae, RAD51 S cerevisiae homolog, RAD51A, RECA, RecA homolog E. coli, RecA like protein, RecA, E. coli, homolog of, recombination protein A.

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.

Gen-ID: 5888

Pathways: DNA Reparatur