TSEN15 Antikörper (AA 1-171)

Produktnummer ABIN7173536

Produktdetails anti-TSEN15 Antikörper

Target: TSEN15 (tRNA Splicing Endonuclease 15 Homolog (TSEN15))

Bindungsspezifität: AA 1-171

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSEN15 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TSEN15

Target: TSEN15 (tRNA Splicing Endonuclease 15 Homolog (TSEN15))

Andere Bezeichnung: TSEN15 (TSEN15 Produkte)

Synonyme: 5730449L18Rik antikoerper, AL023077 antikoerper, Sen15 antikoerper, C1orf19 antikoerper, sen15 antikoerper, tRNA splicing endonuclease subunit 15 antikoerper, Tsen15 antikoerper, TSEN15 antikoerper

Hintergrund:

Background: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\\\' and 3\\\' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2\\\',3\\\' cyclic phosphate and 5\\\'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\\\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\\\'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492).

Aliases: TSEN15 antibody, C1orf19 antibody, SEN15 antibody, tRNA-splicing endonuclease subunit Sen15 antibody, SEN15 homolog antibody, HsSEN15 antibody, tRNA-intron endonuclease Sen15 antibody

UniProt: Q8WW01