TSEN2 Antikörper (AA 1-220)

Produktnummer ABIN7173541

Produktdetails anti-TSEN2 Antikörper

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Bindungsspezifität: AA 1-220

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSEN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human tRNA-splicing endonuclease subunit Sen2 protein (1-220AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:1000, IHC:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TSEN2

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Andere Bezeichnung: TSEN2 (TSEN2 Produkte)

Synonyme: AU067695 antikoerper, RGD1309946 antikoerper, PCH2B antikoerper, SEN2 antikoerper, SEN2L antikoerper, tRNA splicing endonuclease subunit 2 antikoerper, TSEN2 antikoerper, Tsen2 antikoerper

Hintergrund:

Background: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\\\'- and 3\\\'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2\\\',3\\\'-cyclic phosphate and 5\\\'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5\\\'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\\\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\\\'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Aliases: HsSen2 antibody, MGC2776 antibody, MGC4440 antibody, SEN2 antibody, SEN2_HUMAN antibody, SEN2L antibody, tRNA intron endonuclease Sen2 antibody, tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) antibody, tRNA splicing endonuclease subunit Sen2 antibody, tRNA-intron endonuclease sen2 antibody, tRNA-splicing endonuclease subunit Sen2 antibody, TSEN 2 antibody, TSEN2 antibody

UniProt: Q8NCE0

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha