TNFRSF21 Antikörper (AA 371-655)
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- Target Alle TNFRSF21 Antikörper anzeigen
- TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))
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Bindungsspezifität
- AA 371-655
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TNFRSF21 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Kreuzreaktivität
- Human
- Aufreinigung
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Tumor necrosis factor receptor superfamily member 21 protein (371-655AA)
- Isotyp
- IgG
- Top Product
- Discover our top product TNFRSF21 Primärantikörper
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- Applikationshinweise
- Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))
- Andere Bezeichnung
- TNFRSF21 (TNFRSF21 Produkte)
- Synonyme
- TNFRSF21 antikoerper, tnfrsf21 antikoerper, MGC146356 antikoerper, BM-018 antikoerper, CD358 antikoerper, DR6 antikoerper, AA959878 antikoerper, R74815 antikoerper, TR7 antikoerper, dr6 antikoerper, im:6795346 antikoerper, wu:fa55e01 antikoerper, wu:fb02e11 antikoerper, wu:fc29a09 antikoerper, wu:fi27h08 antikoerper, TNF receptor superfamily member 21 antikoerper, tumor necrosis factor receptor superfamily member 21 antikoerper, tumor necrosis factor receptor superfamily, member 21 antikoerper, TNFRSF21 antikoerper, tnfrsf21 antikoerper, Tnfrsf21 antikoerper
- Hintergrund
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Background: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21, this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
Aliases: TNFRSF 21 antibody, BM 018 antibody, BM018 antibody, CD358 antibody, Death receptor 6 antibody, DR 6 antibody, DR6 antibody, MGC31965 antibody, OTTHUMP00000039915 antibody, TNFR related death receptor 6 antibody, TNFRSF21 antibody, TNFRSF21 protein antibody, TNR21_HUMAN antibody, Tumor necrosis factor receptor superfamily member 21 antibody, Tumor necrosis factor receptor superfamily member 21 precursor antibody
- UniProt
- O75509
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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