TP53INP1 Antikörper (AA 138-205)

Produktnummer ABIN7173917

Produktdetails anti-TP53INP1 Antikörper

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Bindungsspezifität: AA 138-205

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53INP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TP53INP1

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Andere Bezeichnung: TP53INP1 (TP53INP1 Produkte)

Hintergrund:

Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on \'Ser-46\' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Aliases: DKFZp434M1317 antibody, FLJ22139 antibody, p53 damage inducible nuclear protein 1 antibody, p53 dependent damage inducible nuclear protein 1 antibody, p53 inducible nuclear protein 1 antibody, p53 inducible p53DINP1 antibody, p53-dependent damage-inducible nuclear protein 1 antibody, p53DINP1 antibody, SIP antibody, Stress induced protein antibody, Stress-induced protein antibody, T53I1_HUMAN antibody, Teap antibody, TP53 DINP1 antibody, TP53 INP1 antibody, TP53DINP1 antibody, TP53INP1 antibody, TP53INP1A antibody, TP53INP1B antibody, Tumor protein p53 inducible nuclear protein 1 antibody, Tumor protein p53-inducible nuclear protein 1 antibody

UniProt: Q96A56