TDP1 Antikörper (AA 1-260)

Produktnummer ABIN7174129

Produktdetails anti-TDP1 Antikörper

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Bindungsspezifität: AA 1-260

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TDP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:2000, IHC:1:20-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Andere Bezeichnung: TDP1 (TDP1 Produkte)

Synonyme: 2810481F14Rik antikoerper, 4921509N21Rik antikoerper, AI838772 antikoerper, AW493413 antikoerper, E430034L06Rik antikoerper, MLZ-501 antikoerper, SCAN1 antikoerper, tdp1 antikoerper, MGC83708 antikoerper, TDP1 antikoerper, F8M21.60 antikoerper, F8M21_60 antikoerper, tyrosyl-DNA phosphodiesterase 1 antikoerper, tyrosyl-DNA phosphodiesterase 1 antikoerper, tyrosyl-DNA Phosphodiesterase (Tdp1) antikoerper, tyrosyl-DNA phosphodiesterase 1 L homeolog antikoerper, tyrosyl-DNA phosphodiesterase-like protein antikoerper, TDP1 antikoerper, Tc00.1047053511191.10 antikoerper, Tdp1 antikoerper, tdp1.L antikoerper, tdp1 antikoerper, PTRG_11198 antikoerper, MCYG_02121 antikoerper, MGYG_03035 antikoerper

Hintergrund:

Background: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3\\\'-phosphodiester bond, giving rise to DNA with a free 3\\\' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3\\\'-phosphoglycolates on protruding 3\\\' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3\\\'exonuclease activity and can remove a single nucleoside from the 3\\\'end of DNA and RNA molecules with 3\\\'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3\\\'phosphate.

Aliases: AI838772 antibody, AW493413 antibody, FLJ11090 antibody, MGC104252 antibody, MGC112732 antibody, RP24-311F12.2 antibody, SCAN1 antibody, TDP1 antibody, TYDP antibody, TYDP1_HUMAN antibody, Tyr-DNA phosphodiesterase 1 antibody, Tyrosyl-DNA phosphodiesterase 1 antibody

UniProt: Q9NUW8