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Ubiquilin 2 Antikörper (AA 473-542) (Biotin)

UBQLN2 Reaktivität: Human ELISA Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN7174229
  • Target Alle Ubiquilin 2 (UBQLN2) Antikörper anzeigen
    Ubiquilin 2 (UBQLN2)
    Bindungsspezifität
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 473-542
    Reaktivität
    • 48
    • 12
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 43
    • 5
    Kaninchen
    Klonalität
    • 44
    • 4
    Polyklonal
    Konjugat
    • 23
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Ubiquilin 2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 30
    • 23
    • 16
    • 10
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Ubiquilin-2 protein (473-542AA)
    Isotyp
    IgG
    Top Product
    Discover our top product UBQLN2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Ubiquilin 2 (UBQLN2)
    Andere Bezeichnung
    UBQLN2 (UBQLN2 Produkte)
    Synonyme
    ALS15 antikoerper, CHAP1 antikoerper, DSK2 antikoerper, N4BP4 antikoerper, PLIC2 antikoerper, Chap1 antikoerper, Dsk2 antikoerper, HRIHFB2157 antikoerper, Plic-2 antikoerper, Plic2 antikoerper, RGD1563566 antikoerper, UBQLN2 antikoerper, ubiquilin 2 antikoerper, UBQLN2 antikoerper, Ubqln2 antikoerper
    Hintergrund

    Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).

    Aliases: UBQLN2 antibody, N4BP4 antibody, PLIC2 antibody, HRIHFB2157Ubiquilin-2 antibody, Chap1 antibody, DSK2 homolog antibody, Protein linking IAP with cytoskeleton 2 antibody, PLIC-2 antibody, hPLIC-2 antibody, Ubiquitin-like product Chap1/Dsk2 antibody

    UniProt
    Q9UHD9
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