USP2 Antikörper (C-Term)

Produktnummer ABIN7174279

Produktdetails anti-USP2 Antikörper

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Bindungsspezifität: AA 200-430, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 2 protein (200-430AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Andere Bezeichnung: USP2 (USP2 Produkte)

Synonyme: UBP41 antikoerper, USP9 antikoerper, B930035K21Rik antikoerper, Ubp41 antikoerper, UBP-t antikoerper, UBP46 antikoerper, ubp52 antikoerper, ubp66 antikoerper, zgc:92134 antikoerper, ubiquitin specific peptidase 2 antikoerper, ubiquitin specific peptidase 2a antikoerper, USP2 antikoerper, Usp2 antikoerper, usp2a antikoerper

Hintergrund:

Background: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Aliases: 41 kDa ubiquitin specific protease antibody, 41 kDa ubiquitin-specific protease antibody, Deubiquitinating enzyme 2 antibody, Ubiquitin carboxyl terminal hydrolase 2 antibody, Ubiquitin carboxyl-terminal hydrolase 2 antibody, ubiquitin specific peptidase 2 antibody, Ubiquitin specific processing protease 2 antibody, Ubiquitin specific protease 12 antibody, Ubiquitin specific protease 9 antibody, Ubiquitin specific protease, 41kD antibody, Ubiquitin thioesterase 2 antibody, Ubiquitin thiolesterase 2 antibody, Ubiquitin-specific-processing protease 2 antibody, Ubiquitin-specific-processing protease testis antibody, UBP-t antibody, UBP2_HUMAN antibody, UBP41 antibody, USP2 antibody, USP9 antibody

UniProt: O75604