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USP28 Antikörper (AA 430-580)

USP28 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7174303
  • Target Alle USP28 Antikörper anzeigen
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 430-580
    Reaktivität
    • 40
    • 17
    • 2
    • 1
    • 1
    Human
    Wirt
    • 52
    • 2
    • 1
    Kaninchen
    Klonalität
    • 55
    Polyklonal
    Konjugat
    • 17
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser USP28 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 19
    • 13
    • 13
    • 12
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 28 protein (430-580AA)
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Andere Bezeichnung
    USP28 (USP28 Produkte)
    Synonyme
    im:7138195 antikoerper, USP28 antikoerper, 9830148O20Rik antikoerper, AU022237 antikoerper, mKIAA1515 antikoerper, ubiquitin specific peptidase 28 antikoerper, USP28 antikoerper, usp28 antikoerper, Usp28 antikoerper
    Hintergrund

    Background: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).

    Aliases: Deubiquitinating enzyme 28 antibody, KIAA1515 antibody, Ubiquitin carboxyl terminal hydrolase 28 antibody, Ubiquitin carboxyl-terminal hydrolase 28 antibody, ubiquitin carboxyl-terminal hydrolase 28 variant 1 antibody, Ubiquitin specific peptidase 28 antibody, Ubiquitin specific processing protease 28 antibody, Ubiquitin specific protease 28 antibody, Ubiquitin thioesterase 28 antibody, Ubiquitin thiolesterase 28 antibody, Ubiquitin-specific-processing protease 28 antibody, UBP28_HUMAN antibody, USP 28 antibody, USP28 antibody, USP28 protein antibody

    UniProt
    Q96RU2
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