UCHL3 Antikörper (C-Term)

Produktnummer ABIN7174370

Produktdetails anti-UCHL3 Antikörper

Target: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Bindungsspezifität: AA 1-220, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UCHL3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L3 protein (1-220AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu UCHL3

Target: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Andere Bezeichnung: UCHL3 (Uchl3 Produkte)

Synonyme: UCH-L3 antikoerper, UCH-6 antikoerper, RGD1561196 antikoerper, im:6908825 antikoerper, zgc:109963 antikoerper, uchl4 antikoerper, ubiquitin C-terminal hydrolase L3 antikoerper, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) antikoerper, ubiquitin C-terminal hydrolase L3 L homeolog antikoerper, UCHL3 antikoerper, Uchl3 antikoerper, uchl3 antikoerper, uchl3.L antikoerper

Hintergrund:

Background: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3\\\", and exhibits a preference towards \\\'Lys-48\\\'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Aliases: Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody, Ubiquitin thioesterase L3 antibody, Ubiquitin thiolesterase antibody, Ubiquitin thiolesterase L3 antibody, UCH L3 antibody, UCH-L3 antibody, UCHL3 antibody, UCHL3_HUMAN antibody

UniProt: P15374

Pathways: Feeding Behaviour, Positive Regulation of fat Cell Differentiation