UBE2W Antikörper (AA 1-151)
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- Target Alle UBE2W Antikörper anzeigen
- UBE2W (Ubiquitin-Conjugating Enzyme E2W (UBE2W))
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Bindungsspezifität
- AA 1-151
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser UBE2W Antikörper ist unkonjugiert
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Applikation
- ELISA
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Ubiquitin-conjugating enzyme E2 W protein (1-151AA)
- Isotyp
- IgG
- Top Product
- Discover our top product UBE2W Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- UBE2W (Ubiquitin-Conjugating Enzyme E2W (UBE2W))
- Andere Bezeichnung
- UBE2W (UBE2W Produkte)
- Synonyme
- UBE2W antikoerper, im:6905459 antikoerper, si:ch211-193n21.4 antikoerper, ube2wa antikoerper, UBC-16 antikoerper, UBC16 antikoerper, 6130401J04Rik antikoerper, ubiquitin conjugating enzyme E2 W antikoerper, ubiquitin-conjugating enzyme E2W (putative) antikoerper, ubiquitin conjugating enzyme E2 W (putative) antikoerper, ubiquitin conjugating enzyme E2W (putative) antikoerper, ubiquitin-conjugating enzyme E2W antikoerper, UBE2W antikoerper, ube2w antikoerper, Ube2w antikoerper
- Hintergrund
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Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes \'Lys-11\'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.
Aliases: FLJ11011 antibody, hUBC 16 antibody, hUBC16 antibody, Probable ubiquitin conjugating enzyme E2 W antibody, Probable ubiquitin-conjugating enzyme E2 W antibody, UBC 16 antibody, UBC-16 antibody, UBC16 antibody, UBE 2W antibody, ube2w antibody, UBE2W_HUMAN antibody, Ubiquitin carrier protein W antibody, Ubiquitin conjugating enzyme 16 antibody, Ubiquitin conjugating enzyme E2 W antibody, Ubiquitin conjugating enzyme E2W antibody, Ubiquitin protein ligase W antibody, Ubiquitin-protein ligase W antibody
- UniProt
- Q96B02
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