UBE2W Antikörper (AA 1-151) (HRP)

Produktnummer ABIN7174505

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch UBE2W in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für UBE2W Antikörper (AA 1-151) (HRP) (ABIN7174505)

Target: UBE2W (Ubiquitin-Conjugating Enzyme E2W (UBE2W))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2W Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-UBE2W Antikörper (HRP)

Bindungsspezifität: AA 1-151

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 W protein (1-151AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu UBE2W

Target: UBE2W (Ubiquitin-Conjugating Enzyme E2W (UBE2W))

Andere Bezeichnung: UBE2W

Hintergrund:

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes \'Lys-11\'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

Aliases: FLJ11011 antibody, hUBC 16 antibody, hUBC16 antibody, Probable ubiquitin conjugating enzyme E2 W antibody, Probable ubiquitin-conjugating enzyme E2 W antibody, UBC 16 antibody, UBC-16 antibody, UBC16 antibody, UBE 2W antibody, ube2w antibody, UBE2W_HUMAN antibody, Ubiquitin carrier protein W antibody, Ubiquitin conjugating enzyme 16 antibody, Ubiquitin conjugating enzyme E2 W antibody, Ubiquitin conjugating enzyme E2W antibody, Ubiquitin protein ligase W antibody, Ubiquitin-protein ligase W antibody

UniProt: Q96B02