ube3a Antikörper (AA 83-234)

Produktnummer ABIN7174571

Produktdetails anti-ube3a Antikörper

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Bindungsspezifität: AA 83-234

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ube3a Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-protein ligase E3A protein (83-234AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ube3a

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Andere Bezeichnung: UBE3A (ube3a Produkte)

Hintergrund:

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).

Aliases: ANCR antibody, Angelman syndrome antibody, AS antibody, CTCL tumor antigen se37 2 antibody, CTCL tumor antigen se37-2 antibody, E6 AP antibody, E6AP antibody, E6AP ubiquitin protein ligase antibody, E6AP ubiquitin-protein ligase antibody, EPVE6AP antibody, FLJ26981 antibody, HECT-type ubiquitin transferase E3A antibody, HPVE6A antibody, Human papilloma virus E6 associated protein Angelman syndrome antibody, Human papilloma virus E6 associated protein antibody, Human papillomavirus E6-associated protein antibody, NY REN 54 antigen antibody, Oncogenic protein associated protein E6 AP antibody, Oncogenic protein associated protein E6AP antibody, Oncogenic protein-associated protein E6-AP antibody, Renal carcinoma antigen NY REN 54 antibody, Renal carcinoma antigen NY-REN-54 antibody, UBE 3A antibody, Ube3a antibody, UBE3A protein antibody, UBE3A_HUMAN antibody, Ubiquitin protein ligase E3A antibody, Ubiquitin-protein ligase E3A antibody

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway