ULBP1 Antikörper (AA 26-216) (Biotin)

Produktnummer ABIN7174679

Produktdetails anti-ULBP1 Antikörper (Biotin)

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Bindungsspezifität: AA 26-216

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULBP1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human UL16-binding protein 1 protein (26-216AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ULBP1

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Andere Bezeichnung: ULBP1 (ULBP1 Produkte)

Synonyme: RAET1I antikoerper, A430108B07Rik antikoerper, MULT1 antikoerper, ULBP1 antikoerper, UL16 binding protein 1 antikoerper, UL16 binding protein 21 antikoerper, NKG2D ligand 1 antikoerper, ULBP1 antikoerper, ULBP21 antikoerper, Ulbp1 antikoerper, LOC100683099 antikoerper

Hintergrund:

Background: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Aliases: Alcan beta antibody, ALCAN-beta antibody, N2DL-1 antibody, N2DL1 antibody, N2DL1_HUMAN antibody, NKG2D ligand 1 antibody, NKG2D ligand 1 precursor antibody, NKG2DL1 antibody, RAET1I antibody, Retinoic acid early transcript 1I antibody, UL16 antibody, UL16 binding protein 1 antibody, UL16-binding protein 1 antibody, ULBP1 antibody

UniProt: Q9BZM6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process