VPS11 Antikörper (AA 692-941)

Produktnummer ABIN7175282

Produktdetails anti-VPS11 Antikörper

Target: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Bindungsspezifität: AA 692-941

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS11 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VPS11

Target: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Andere Bezeichnung: VPS11 (VPS11 Produkte)

Hintergrund:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Aliases: END1 antibody, HGNC:14583 antibody, hVPS11 antibody, PEP5 antibody, PP3476 antibody, RING finger protein 108 antibody, RNF108 antibody, Vacuolar protein sorting 11 (yeast homolog) antibody, Vacuolar protein sorting 11 (yeast) antibody, Vacuolar protein sorting 11 homolog (S. cerevisiae) antibody, Vacuolar protein sorting 11 homolog antibody, Vacuolar protein sorting associated protein 11 homolog antibody, Vacuolar protein sorting protein 11 antibody, Vacuolar protein sorting-associated protein 11 homolog antibody, vps11 antibody, VPS11_HUMAN antibody

UniProt: Q9H270

Pathways: SARS-CoV-2 Protein Interaktom