VPS18 Antikörper (AA 298-515)

Produktnummer ABIN7175284

Produktdetails anti-VPS18 Antikörper

Target: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Bindungsspezifität: AA 298-515

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS18 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 18 homolog protein (298-515AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VPS18

Target: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Andere Bezeichnung: VPS18 (VPS18 Produkte)

Hintergrund:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).

Aliases: hVPS18 antibody, PEP3 antibody, Vacuolar protein sorting 18 antibody, Vacuolar protein sorting protein 18 antibody, Vacuolar protein sorting-associated protein 18 homolog antibody, vps18 antibody, VPS18_HUMAN antibody

UniProt: Q9P253

Pathways: Asymmetric Protein Localization