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WDR61 Antikörper (AA 2-305)

WDR61 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7175778
  • Target Alle WDR61 Antikörper anzeigen
    WDR61 (WD Repeat Domain 61 (WDR61))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    AA 2-305
    Reaktivität
    • 37
    • 17
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 46
    • 6
    Kaninchen
    Klonalität
    • 48
    • 4
    Polyklonal
    Konjugat
    • 18
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser WDR61 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 22
    • 13
    • 13
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human WD repeat-containing protein 61 protein (2-305AA)
    Isotyp
    IgG
    Top Product
    Discover our top product WDR61 Primärantikörper
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    WDR61 (WD Repeat Domain 61 (WDR61))
    Andere Bezeichnung
    WDR61 (WDR61 Produkte)
    Synonyme
    WDR61 antikoerper, REC14 antikoerper, SKI8 antikoerper, 2700038L12Rik antikoerper, 2810418I05Rik antikoerper, RGD1308228 antikoerper, WD repeat domain 61 antikoerper, Ski complex subunit Rec14 antikoerper, WD repeat domain 61 L homeolog antikoerper, wdr61 antikoerper, WDR61 antikoerper, LOC692852 antikoerper, LOC732907 antikoerper, rec14 antikoerper, Wdr61 antikoerper, wdr61.L antikoerper
    Hintergrund

    Background: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and \\\'Ser-2\\\'- and \\\'Ser-5\\\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \\\'Lys-4\\\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\\\' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 \\\'Lys-4\\\' (H3K4me3), dimethylation on histone H3 \\\'Lys-79\\\' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

    Aliases: Meiotic recombination REC14 protein homolog antibody, REC14 antibody, Recombination protein REC14 antibody, Ski8 antibody, SKI8 homolog antibody, WD repeat containing protein 61 antibody, WD repeat domain 61 antibody, WD repeat-containing protein 61 antibody, WDR 61 antibody, wdr61 antibody, WDR61_HUMAN antibody

    UniProt
    Q9GZS3
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