YTHDC1 Antikörper (AA 89-153)

Produktnummer ABIN7175950

Produktdetails anti-YTHDC1 Antikörper

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Bindungsspezifität: AA 89-153

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YTHDC1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human YTH domain-containing protein 1 protein (89-153AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu YTHDC1

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Andere Bezeichnung: YTHDC1 (YTHDC1 Produkte)

Synonyme: C80342 antikoerper, mKIAA1966 antikoerper, A730098D12Rik antikoerper, zgc:101592 antikoerper, MGC89461 antikoerper, MGC137509 antikoerper, DKFZp459L1228 antikoerper, YT521 antikoerper, YT521-B antikoerper, Yt521 antikoerper, YTH domain containing 1 antikoerper, YTH domain containing 1 L homeolog antikoerper, Ythdc1 antikoerper, YTHDC1 antikoerper, ythdc1 antikoerper, ythdc1.L antikoerper

Hintergrund:

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).

Aliases: YTHDC1 antibody, KIAA1966 antibody, YT521 antibody, YTH domain-containing protein 1 antibody, Splicing factor YT521 antibody, YT521-B antibody

UniProt: Q96MU7