RAC1 Antikörper (pSer71)

Produktnummer ABIN713411

Produktdetails anti-RAC1 Antikörper

Target: RAC1

Bindungsspezifität: pSer71

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human RAC1 around the phosphorylation site of Ser71

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu RAC1

Target: RAC1

Abstract: RAC1 Produkte

Synonyme: Rac-1 antikoerper, TC-25 antikoerper, p21-Rac1 antikoerper, AL023026 antikoerper, D5Ertd559e antikoerper, RAC2 antikoerper, CRAC1A antikoerper, rac1 antikoerper, wu:fd16e02 antikoerper, zgc:55823 antikoerper, zgc:55917 antikoerper, zgc:86934 antikoerper, 2248 antikoerper, CG2248 antikoerper, D-Rac antikoerper, D-Rac 1 antikoerper, D-Rac1 antikoerper, DRac antikoerper, DRac1 antikoerper, DRacA antikoerper, Dm Rac1 antikoerper, DmRAC antikoerper, DmRAC1 antikoerper, Dmel\CG2248 antikoerper, Dmrac1 antikoerper, Drac antikoerper, Drac1 antikoerper, Drac1a antikoerper, DracA antikoerper, GTPase Rac1 antikoerper, P40792 antikoerper, RAC1 antikoerper, Rac antikoerper, Rac GTPase antikoerper, Rac3 antikoerper, RacA antikoerper, dRac antikoerper, dRac1 antikoerper, drac1 antikoerper, rac antikoerper, Xrac antikoerper, mig5 antikoerper, p21-rac1 antikoerper, tc-25 antikoerper, Rac family small GTPase 1 antikoerper, RAS-related C3 botulinum substrate 1 antikoerper, ras-related C3 botulinum toxin substrate 1 antikoerper, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) antikoerper, Rac family small GTPase 1a antikoerper, CG2248 gene product from transcript CG2248-RB antikoerper, Rac family small GTPase 1 L homeolog antikoerper, ras homolog family member G antikoerper, RAC1 antikoerper, Rac1 antikoerper, rac1a antikoerper, rac1.L antikoerper, RHOG antikoerper

Hintergrund:

Synonyms: MIG5, Rac-1, TC-25, p21-Rac1, Ras-related C3 botulinum toxin substrate 1, Cell migration-inducing gene 5 protein, Ras-like protein TC25, RAC1, TC25

Background: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2, this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

Gen-ID: 5879

UniProt: P63000

Pathways: WNT Signalweg, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Thromboxane A2 Receptor Signaling, VEGF Signaling