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RIPK1 Antikörper (AA 1-656)

RIPK1 Reaktivität: Maus WB, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7177814
  • Target Alle RIPK1 Antikörper anzeigen
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Bindungsspezifität
    • 16
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-656
    Reaktivität
    • 85
    • 39
    • 28
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 80
    • 10
    Kaninchen
    Klonalität
    • 72
    • 18
    Polyklonal
    Konjugat
    • 34
    • 9
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RIPK1 Antikörper ist unkonjugiert
    Applikation
    • 59
    • 32
    • 19
    • 15
    • 13
    • 13
    • 10
    • 10
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 protein (1-656AA)
    Isotyp
    IgG
    Top Product
    Discover our top product RIPK1 Primärantikörper
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000, IP:1:200-1:2000,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Andere Bezeichnung
    Ripk1 (RIPK1 Produkte)
    Synonyme
    RIP antikoerper, RIP1 antikoerper, D330015H01Rik antikoerper, Rinp antikoerper, Rip1 antikoerper, rip1 antikoerper, ripk1 antikoerper, xRIP1beta antikoerper, xrip1 antikoerper, receptor interacting serine/threonine kinase 1 antikoerper, receptor (TNFRSF)-interacting serine-threonine kinase 1 antikoerper, receptor interacting serine/threonine kinase 1 L homeolog antikoerper, RIPK1 antikoerper, Ripk1 antikoerper, ripk1.L antikoerper
    Hintergrund

    Background: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \\\'Ser-728\\\' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \\\'Lys-63\\\'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).

    Aliases: Ripk1 antibody, Rinp antibody, Rip antibody, Receptor-interacting serine/threonine-protein kinase 1 antibody, EC 2.7.11.1 antibody, Cell death protein RIP antibody, Receptor-interacting protein 1 antibody, RIP-1 antibody

    UniProt
    Q60855
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Ubiquitin Proteasome Pathway
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