CTCFL Antikörper (AA 1-636) (HRP)
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- Target Alle CTCFL Antikörper anzeigen
- CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))
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Bindungsspezifität
- AA 1-636
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CTCFL Antikörper ist konjugiert mit HRP
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Applikation
- ELISA
- Kreuzreaktivität
- Maus
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Mouse Transcriptional repressor CTCFL protein (1-636AA)
- Isotyp
- IgG
- Top Product
- Discover our top product CTCFL Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))
- Andere Bezeichnung
- Ctcfl (CTCFL Produkte)
- Synonyme
- BORIS antikoerper, CT27 antikoerper, CTCF-T antikoerper, HMGB1L1 antikoerper, dJ579F20.2 antikoerper, CTCFL antikoerper, Boris antikoerper, OTTMUSG00000016680 antikoerper, CCCTC-binding factor like antikoerper, CCCTC-binding factor (zinc finger protein)-like antikoerper, CTCFL antikoerper, Ctcfl antikoerper
- Hintergrund
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Background: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \\\'Arg-3\\\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Aliases: Ctcfl antibody, Boris antibody, Transcriptional repressor CTCFL antibody, Brother of the regulator of imprinted sites antibody, CCCTC-binding factor antibody, CTCF paralog antibody, CTCF-like protein antibody
- UniProt
- A2APF3
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